The Reds have been boosted by their recent win against Aston Villa, which brought an end to a four-match losing run in the league.
However, City have been in impressive form, with four wins and one loss in their five Premier League home games this season.
In fact, City have been the Premier League's best team in terms of results since the beginning of April, with 42 points won and 13 victories in 19 games.
The match will also see two of the Premier League's top stars, Mohamed Salah and Erling Haaland, in action.
Salah is just one goal away from breaking Wayne Rooney's record for the most Premier League goal involvements at a single club, while Haaland is on the verge of becoming the fastest player in Premier League history to reach a century of goals.
Guardiola, meanwhile, will be overseeing his 1,000th match as a manager, and his side will be looking to make it a special milestone.
Liverpool, however, will be determined to spoil the party and claim a much-needed win against their fierce rivals.
